High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition

The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics, chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate sites on the bacterial ribosome: the catalytic peptidyl transferase center (PTC) and the nascent polypeptide exit tu...

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Published in:RNA
Main Authors: Svetlov, Maxim S., Plessa, Elena, Chen, Chih-Wei, Bougas, Anthony, Krokidis, Marios G., Dinos, George P., Polikanov, Yury S.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467010/
https://ncbi.nlm.nih.gov/pubmed/30733327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.069260.118
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