Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents

[Image: see text] Targeted approaches aiming at modulating NHERF1 activity, rather than its overall expression, would be preferred to preserve the normal functions of this versatile protein. We focused our attention on the NHERF1/PDZ1 domain that governs its membrane recruitment/displacement through...

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Publicado en:ACS Med Chem Lett
Autores principales: Coluccia, Antonio, La Regina, Giuseppe, Naccarato, Valentina, Nalli, Marianna, Orlando, Viviana, Biagioni, Stefano, De Angelis, Maria Laura, Baiocchi, Marta, Gautier, Candice, Gianni, Stefano, Di Pastena, Fiorella, Di Magno, Laura, Canettieri, Gianluca, Coluccia, Addolorata Maria Luce, Silvestri, Romano
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2019
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466550/
https://ncbi.nlm.nih.gov/pubmed/30996786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00532
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