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Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95

PDZ domains are one of the most important protein-protein interaction domains in human. While presenting a conserved three dimensional structure, a substantial number of PDZ domains display structural extensions suggested to be involved in their folding and binding mechanisms. The C-terminal α-helix...

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Foilsithe in:Sci Rep
Main Authors: Gautier, Candice, Visconti, Lorenzo, Jemth, Per, Gianni, Stefano
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626748/
https://ncbi.nlm.nih.gov/pubmed/28974728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12827-0
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