Sequence-specific Long Range Networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity

Protein-protein interactions mediated by modular protein domains are critical for cell scaffolding, differentiation, signaling, and ultimately, evolution. Given the vast number of ligands competing for binding to a limited number of domain families, it is often puzzling how specificity can be achiev...

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Detalhes bibliográficos
Main Authors: Gianni, Stefano, Haq, S. Raza, Montemiglio, Linda C., Jürgens, Maike C., Engström, Åke, Chi, Celestine N., Brunori, Maurizio, Jemth, Per
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149310/
https://ncbi.nlm.nih.gov/pubmed/21653701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.239541
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