Protein Interacting with C-kinase 1 (PICK1) Binding Promiscuity Relies on Unconventional PSD-95/Discs-Large/ZO-1 Homology (PDZ) Binding Modes for Nonclass II PDZ Ligands

PDZ domain proteins control multiple cellular functions by governing assembly of protein complexes. It remains unknown why individual PDZ domains can bind the extreme C terminus of very diverse binding partners and maintain selectivity. By employing NMR spectroscopy, together with molecular modeling...

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Detalhes bibliográficos
Main Authors: Erlendsson, Simon, Rathje, Mette, Heidarsson, Pétur O., Poulsen, Flemming M., Madsen, Kenneth L., Teilum, Kaare, Gether, Ulrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155694/
https://ncbi.nlm.nih.gov/pubmed/25023278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548743
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