Protein Interacting with C-kinase 1 (PICK1) Binding Promiscuity Relies on Unconventional PSD-95/Discs-Large/ZO-1 Homology (PDZ) Binding Modes for Nonclass II PDZ Ligands

PDZ domain proteins control multiple cellular functions by governing assembly of protein complexes. It remains unknown why individual PDZ domains can bind the extreme C terminus of very diverse binding partners and maintain selectivity. By employing NMR spectroscopy, together with molecular modeling...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Erlendsson, Simon, Rathje, Mette, Heidarsson, Pétur O., Poulsen, Flemming M., Madsen, Kenneth L., Teilum, Kaare, Gether, Ulrik
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155694/
https://ncbi.nlm.nih.gov/pubmed/25023278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548743
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk