Protein Interacting with C-kinase 1 (PICK1) Binding Promiscuity Relies on Unconventional PSD-95/Discs-Large/ZO-1 Homology (PDZ) Binding Modes for Nonclass II PDZ Ligands

PDZ domain proteins control multiple cellular functions by governing assembly of protein complexes. It remains unknown why individual PDZ domains can bind the extreme C terminus of very diverse binding partners and maintain selectivity. By employing NMR spectroscopy, together with molecular modeling...

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Autores principales: Erlendsson, Simon, Rathje, Mette, Heidarsson, Pétur O., Poulsen, Flemming M., Madsen, Kenneth L., Teilum, Kaare, Gether, Ulrik
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155694/
https://ncbi.nlm.nih.gov/pubmed/25023278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548743
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