Protein Interacting with C-kinase 1 (PICK1) Binding Promiscuity Relies on Unconventional PSD-95/Discs-Large/ZO-1 Homology (PDZ) Binding Modes for Nonclass II PDZ Ligands

PDZ domain proteins control multiple cellular functions by governing assembly of protein complexes. It remains unknown why individual PDZ domains can bind the extreme C terminus of very diverse binding partners and maintain selectivity. By employing NMR spectroscopy, together with molecular modeling...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Erlendsson, Simon, Rathje, Mette, Heidarsson, Pétur O., Poulsen, Flemming M., Madsen, Kenneth L., Teilum, Kaare, Gether, Ulrik
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155694/
https://ncbi.nlm.nih.gov/pubmed/25023278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548743
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