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Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
Circular permutation is a common molecular mechanism for evolution of proteins. However, such re-arrangement of secondary structure connectivity may interfere with the folding mechanism causing accumulation of folding intermediates, which in turn can lead to misfolding. We solved the crystal structu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3503759/ https://ncbi.nlm.nih.gov/pubmed/23185531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050055 |
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