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Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

Circular permutation is a common molecular mechanism for evolution of proteins. However, such re-arrangement of secondary structure connectivity may interfere with the folding mechanism causing accumulation of folding intermediates, which in turn can lead to misfolding. We solved the crystal structu...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Hultqvist, Greta, Punekar, Avinash S., Morrone, Angela, Chi, Celestine N., Engström, Åke, Selmer, Maria, Gianni, Stefano, Jemth, Per
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503759/
https://ncbi.nlm.nih.gov/pubmed/23185531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050055
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