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Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

Circular permutation is a common molecular mechanism for evolution of proteins. However, such re-arrangement of secondary structure connectivity may interfere with the folding mechanism causing accumulation of folding intermediates, which in turn can lead to misfolding. We solved the crystal structu...

詳細記述

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書誌詳細
主要な著者: Hultqvist, Greta, Punekar, Avinash S., Morrone, Angela, Chi, Celestine N., Engström, Åke, Selmer, Maria, Gianni, Stefano, Jemth, Per
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503759/
https://ncbi.nlm.nih.gov/pubmed/23185531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050055
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