Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents

[Image: see text] Targeted approaches aiming at modulating NHERF1 activity, rather than its overall expression, would be preferred to preserve the normal functions of this versatile protein. We focused our attention on the NHERF1/PDZ1 domain that governs its membrane recruitment/displacement through...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Coluccia, Antonio, La Regina, Giuseppe, Naccarato, Valentina, Nalli, Marianna, Orlando, Viviana, Biagioni, Stefano, De Angelis, Maria Laura, Baiocchi, Marta, Gautier, Candice, Gianni, Stefano, Di Pastena, Fiorella, Di Magno, Laura, Canettieri, Gianluca, Coluccia, Addolorata Maria Luce, Silvestri, Romano
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466550/
https://ncbi.nlm.nih.gov/pubmed/30996786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00532
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires