Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression

Impaired functional plasma membrane (PM) expression of the hERG K(+)-channel is associated with Long-QT syndrome type-2 (LQT2) and increased risk of cardiac arrhythmia. Reduced PM-expression is primarily attributed to retention and degradation of misfolded channels by endoplasmic reticulum (ER) prot...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Foo, Brian, Barbier, Camille, Guo, Kevin, Vasantharuban, Jaminie, Lukacs, Gergely L., Shrier, Alvin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465299/
https://ncbi.nlm.nih.gov/pubmed/30988392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42331-6
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