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Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression
Impaired functional plasma membrane (PM) expression of the hERG K(+)-channel is associated with Long-QT syndrome type-2 (LQT2) and increased risk of cardiac arrhythmia. Reduced PM-expression is primarily attributed to retention and degradation of misfolded channels by endoplasmic reticulum (ER) prot...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6465299/ https://ncbi.nlm.nih.gov/pubmed/30988392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42331-6 |
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