A mutually induced conformational fit underlies Ca(2+)-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K(+) channels

Calmodulin (CaM) conveys intracellular Ca(2+) signals to KCNQ (Kv7, “M-type”) K(+) channels and many other ion channels. Whether this “calmodulation” involves a dramatic structural rearrangement or only slight perturbations of the CaM/KCNQ complex is as yet unclear. A consensus structural model of c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Archer, Crystal R., Enslow, Benjamin T., Taylor, Alexander B., De la Rosa, Victor, Bhattacharya, Akash, Shapiro, Mark S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2019
Pynciau:
Molecular Biophysics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463706/
https://ncbi.nlm.nih.gov/pubmed/30808708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006857
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg