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A mutually induced conformational fit underlies Ca(2+)-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K(+) channels
Calmodulin (CaM) conveys intracellular Ca(2+) signals to KCNQ (Kv7, “M-type”) K(+) channels and many other ion channels. Whether this “calmodulation” involves a dramatic structural rearrangement or only slight perturbations of the CaM/KCNQ complex is as yet unclear. A consensus structural model of c...
Sparad:
I publikationen: | J Biol Chem |
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Huvudupphovsmän: | , , , , , |
Materialtyp: | Artigo |
Språk: | Inglês |
Publicerad: |
American Society for Biochemistry and Molecular Biology
2019
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Ämnen: | |
Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6463706/ https://ncbi.nlm.nih.gov/pubmed/30808708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006857 |
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