A mutually induced conformational fit underlies Ca(2+)-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K(+) channels

Calmodulin (CaM) conveys intracellular Ca(2+) signals to KCNQ (Kv7, “M-type”) K(+) channels and many other ion channels. Whether this “calmodulation” involves a dramatic structural rearrangement or only slight perturbations of the CaM/KCNQ complex is as yet unclear. A consensus structural model of c...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Archer, Crystal R., Enslow, Benjamin T., Taylor, Alexander B., De la Rosa, Victor, Bhattacharya, Akash, Shapiro, Mark S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463706/
https://ncbi.nlm.nih.gov/pubmed/30808708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006857
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