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Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity
Deregulation of the HECT-type ubiquitin ligase E6AP (UBE3A) is implicated in human papilloma virus-induced cervical tumorigenesis and several neurodevelopmental disorders. Yet the structural underpinnings of activity and specificity in this crucial ligase are incompletely understood. Here, we unrave...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6463701/ https://ncbi.nlm.nih.gov/pubmed/30737286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007014 |
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