The HECT Domain of the Ubiquitin Ligase Rsp5 Contributes to Substrate Recognition

Ubiquitin modification of endosomal membrane proteins is a signal for active inclusion into the Multivesicular Body (MVB) pathway, resulting in lysosomal degradation. However, the endosome represents a dynamic site of protein sorting with a majority of proteins destined for recycling, rather than MV...

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Autori principali: Lee, Jacqueline R. E., Oestreich, Andrea J., Payne, Johanna A., Gunawan, Mia S., Norgan, Andrew P., Katzmann, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Protein Synthesis, Post-Translational Modification, and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797283/
https://ncbi.nlm.nih.gov/pubmed/19744925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048629
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