Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity

Deregulation of the HECT-type ubiquitin ligase E6AP (UBE3A) is implicated in human papilloma virus-induced cervical tumorigenesis and several neurodevelopmental disorders. Yet the structural underpinnings of activity and specificity in this crucial ligase are incompletely understood. Here, we unrave...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ries, Lena K., Sander, Bodo, Deol, Kirandeep K., Letzelter, Marie-Annick, Strieter, Eric Robert, Lorenz, Sonja
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463701/
https://ncbi.nlm.nih.gov/pubmed/30737286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007014
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