The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface

Most clinically available antipsychotic drugs (APDs) bind dopamine D2 receptors (D2R) at therapeutic concentrations, and it is thought that they suppress psychotic symptoms by serving as competitive antagonists of dopamine at D2R. Here, we present data that demonstrate that APDs act independently of...

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Udgivet i:J Biol Chem
Main Authors: Schrader, Joseph M., Irving, Craig M., Octeau, J. Christopher, Christian, Joseph A., Aballo, Timothy J., Kareemo, Dean J., Conti, Joseph, Camberg, Jodi L., Lane, J. Robert, Javitch, Jonathan A., Kovoor, Abraham
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462534/
https://ncbi.nlm.nih.gov/pubmed/30670597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004682
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