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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D(2) receptors

Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D(2) receptor. However, support for this hypothesis is limited to a relatively small number of observations made across several decades and u...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert, Charlton, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624946/
https://ncbi.nlm.nih.gov/pubmed/28970469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00716-z
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