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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D(2) receptors

Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D(2) receptor. However, support for this hypothesis is limited to a relatively small number of observations made across several decades and u...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert, Charlton, Steven J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624946/
https://ncbi.nlm.nih.gov/pubmed/28970469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00716-z
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