The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface

Most clinically available antipsychotic drugs (APDs) bind dopamine D2 receptors (D2R) at therapeutic concentrations, and it is thought that they suppress psychotic symptoms by serving as competitive antagonists of dopamine at D2R. Here, we present data that demonstrate that APDs act independently of...

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Опубликовано в: :J Biol Chem
Главные авторы: Schrader, Joseph M., Irving, Craig M., Octeau, J. Christopher, Christian, Joseph A., Aballo, Timothy J., Kareemo, Dean J., Conti, Joseph, Camberg, Jodi L., Lane, J. Robert, Javitch, Jonathan A., Kovoor, Abraham
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462534/
https://ncbi.nlm.nih.gov/pubmed/30670597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004682
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