The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface

Most clinically available antipsychotic drugs (APDs) bind dopamine D2 receptors (D2R) at therapeutic concentrations, and it is thought that they suppress psychotic symptoms by serving as competitive antagonists of dopamine at D2R. Here, we present data that demonstrate that APDs act independently of...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Schrader, Joseph M., Irving, Craig M., Octeau, J. Christopher, Christian, Joseph A., Aballo, Timothy J., Kareemo, Dean J., Conti, Joseph, Camberg, Jodi L., Lane, J. Robert, Javitch, Jonathan A., Kovoor, Abraham
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462534/
https://ncbi.nlm.nih.gov/pubmed/30670597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004682
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