Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response

To investigate how chromatin architecture is spatiotemporally organized at a double-strand break (DSB) repair locus, we established a biophysical method to quantify chromatin compaction at the nucleosome level during the DNA damage response (DDR). The method is based on phasor image-correlation spec...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lou, Jieqiong, Scipioni, Lorenzo, Wright, Belinda K., Bartolec, Tara K., Zhang, Jessie, Masamsetti, V. Pragathi, Gaus, Katharina, Gratton, Enrico, Cesare, Anthony J., Hinde, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462080/
https://ncbi.nlm.nih.gov/pubmed/30918123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814965116
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