Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

BACKGROUND: Testicular germ cell cancer (TGCC), being the most frequent malignancy in young Caucasian males, is initiated from an embryonic germ cell. This study determines intratumour heterogeneity to unravel tumour progression from initiation until metastasis. METHODS: In total, 42 purified sample...

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Pubblicato in:Br J Cancer
Autori principali: Dorssers, Lambert C. J., Gillis, Ad J. M., Stoop, Hans, van Marion, Ronald, Nieboer, Marleen M., van Riet, Job, van de Werken, Harmen J. G., Oosterhuis, J. Wolter, de Ridder, Jeroen, Looijenga, Leendert H. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461884/
https://ncbi.nlm.nih.gov/pubmed/30739914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0381-1
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