MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats

Vascular pathophysiological changes after haemorrhagic stroke, such as phenotypic modulation of the cerebral arteries and cerebral vasospasms, are associated with delayed cerebral ischemia (DCI) and poor outcome. The only currently approved drug treatment shown to reduce the risk of DCI and improve...

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Vydáno v:PLoS One
Hlavní autoři: Christensen, Simon T., Johansson, Sara E., Radziwon-Balicka, Aneta, Warfvinge, Karin, Haanes, Kristian A., Edvinsson, Lars
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461292/
https://ncbi.nlm.nih.gov/pubmed/30978262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215398
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