MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats

Vascular pathophysiological changes after haemorrhagic stroke, such as phenotypic modulation of the cerebral arteries and cerebral vasospasms, are associated with delayed cerebral ischemia (DCI) and poor outcome. The only currently approved drug treatment shown to reduce the risk of DCI and improve...

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Опубликовано в: :PLoS One
Главные авторы: Christensen, Simon T., Johansson, Sara E., Radziwon-Balicka, Aneta, Warfvinge, Karin, Haanes, Kristian A., Edvinsson, Lars
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461292/
https://ncbi.nlm.nih.gov/pubmed/30978262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215398
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