L-ascorbic acid: A true substrate for HIF prolyl hydroxylase?

L-Ascorbate (L-Asc), but not D-isoascorbate (D-Asc) and N-acetylcysteine (NAC) suppress HIF1 ODD-luc reporter activation induced by various inhibitors of HIF prolyl hydroxylase (PHD). The efficiency of suppression by L-Asc was sensitive to the nature of HIF PHD inhibitor chosen for reporter activati...

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Bibliographic Details
Published in:Biochimie
Main Authors: Osipyants, Andrey I., Poloznikov, Andrey A., Smirnova, Natalya A., Hushpulian, Dmitry M., Khristichenko, Anna Yu., Chubar, Tatiana A., Zakhariants, Arpenik A., Ahuja, Manuj, Gaisina, Irina N., Thomas, Bobby, Brown, Abe M., Gazaryan, Irina G., Tishkov, Vladimir I.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460286/
https://ncbi.nlm.nih.gov/pubmed/29289682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2017.12.011
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