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Endosomal pH favors shedding of membrane‐inserted amyloid‐β peptide
Amyloid‐β peptides (Aβs) are generated in a membrane‐embedded state by sequential processing of amyloid precursor protein (APP). Although shedding of membrane‐embedded Aβ is essential for its secretion and neurotoxicity, the mechanism behind shedding regulation is not fully elucidated. Thus, we devi...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6460001/ https://ncbi.nlm.nih.gov/pubmed/30825227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3596 |
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