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Endosomal pH favors shedding of membrane‐inserted amyloid‐β peptide

Amyloid‐β peptides (Aβs) are generated in a membrane‐embedded state by sequential processing of amyloid precursor protein (APP). Although shedding of membrane‐embedded Aβ is essential for its secretion and neurotoxicity, the mechanism behind shedding regulation is not fully elucidated. Thus, we devi...

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Bibliografiska uppgifter
I publikationen:Protein Sci
Huvudupphovsmän: Shi, Jing‐Ming, Lv, Jian‐Min, Gao, Bo‐Xuan, Zhang, Lin, Ji, Shang‐Rong
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley & Sons, Inc. 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460001/
https://ncbi.nlm.nih.gov/pubmed/30825227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3596
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