Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins

Emerging viruses such as severe fever and thrombocytopenia syndrome virus (SFTSV) and Ebola virus (EBOV) are responsible for significant morbidity and mortality. Host cell proteases that process the glycoproteins of these viruses are potential targets for antiviral intervention. The aspartyl proteas...

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Udgivet i:PLoS One
Main Authors: Plegge, Teresa, Spiegel, Martin, Krüger, Nadine, Nehlmeier, Inga, Winkler, Michael, González Hernández, Mariana, Pöhlmann, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459477/
https://ncbi.nlm.nih.gov/pubmed/30973897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214968
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