Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for treating genetic diseases. However, responses triggered by programmable nucleases in HSPCs are poorly characterized and may negatively impact HSPC engraftment and long-term repopulation capacity. Here, we induc...

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Foilsithe in:Cell Stem Cell
Main Authors: Schiroli, Giulia, Conti, Anastasia, Ferrari, Samuele, della Volpe, Lucrezia, Jacob, Aurelien, Albano, Luisa, Beretta, Stefano, Calabria, Andrea, Vavassori, Valentina, Gasparini, Patrizia, Salataj, Eralda, Ndiaye-Lobry, Delphine, Brombin, Chiara, Chaumeil, Julie, Montini, Eugenio, Merelli, Ivan, Genovese, Pietro, Naldini, Luigi, Di Micco, Raffaella
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cell Press 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458988/
https://ncbi.nlm.nih.gov/pubmed/30905619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.02.019
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