An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program

Hematopoietic stem and progenitor cells (HSPC) reside in the bone marrow (BM) niche and serve as a reservoir for mature blood cells throughout life. Aging in the BM is characterized by low‐grade chronic inflammation that could contribute to the reduced functionality of aged HSPC. Mesenchymal stromal...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:Aging Cell
Główni autorzy: Gnani, Daniela, Crippa, Stefania, della Volpe, Lucrezia, Rossella, Valeria, Conti, Anastasia, Lettera, Emanuele, Rivis, Silvia, Ometti, Marco, Fraschini, Gianfranco, Bernardo, Maria Ester, Di Micco, Raffaella
Format: Artigo
Język:Inglês
Wydane: John Wiley and Sons Inc. 2019
Hasła przedmiotowe:
Original Papers
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516180/
https://ncbi.nlm.nih.gov/pubmed/30828977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12933
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