Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening

Synthetic mRNA has emerged as a powerful tool for the transfer of genetic information, and it is being explored for a variety of therapeutic applications. Many of these applications require prolonged intracellular persistence of mRNA to improve bioavailability of the encoded protein. mRNA molecules...

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Udgivet i:Mol Ther
Main Authors: Orlandini von Niessen, Alexandra G., Poleganov, Marco A., Rechner, Corina, Plaschke, Arianne, Kranz, Lena M., Fesser, Stephanie, Diken, Mustafa, Löwer, Martin, Vallazza, Britta, Beissert, Tim, Bukur, Valesca, Kuhn, Andreas N., Türeci, Özlem, Sahin, Ugur
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453560/
https://ncbi.nlm.nih.gov/pubmed/30638957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.12.011
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