A liposomal RNA vaccine inducing neoantigen-specific CD4(+) T cells augments the antitumor activity of local radiotherapy in mice

Antigen-encoding, lipoplex-formulated RNA (RNA-LPX) enables systemic delivery to lymphoid compartments and selective expression in resident antigen-presenting cells. We report here that the rejection of CT26 tumors, mediated by local radiotherapy (LRT), is further augmented in a CD8(+) T cell-depend...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Salomon, Nadja, Vascotto, Fulvia, Selmi, Abderaouf, Vormehr, Mathias, Quinkhardt, Juliane, Bukur, Thomas, Schrörs, Barbara, Löewer, Martin, Diken, Mustafa, Türeci, Özlem, Sahin, Ugur, Kreiter, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458669/
https://ncbi.nlm.nih.gov/pubmed/32923128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1771925
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