Single cell analysis of clonal architecture in acute myeloid leukaemia

We used single cell Q-PCR on a micro-fluidic platform (Fluidigm) to analyse clonal, genetic architecture and phylogeny in acute myeloid leukaemia (AML) using selected mutations. Ten cases of NPM1c mutant AML were screened for 111 mutations that are recurrent in AML and cancer. Clonal architectures w...

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Publicat a:Leukemia
Autors principals: Potter, Nicola, Miraki-Moud, Farideh, Ermini, Luca, Titley, Ian, Vijayaraghavan, Gowri, Papaemmanuil, Elli, Campbell, Peter, Gribben, John, Taussig, David, Greaves, Mel
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451634/
https://ncbi.nlm.nih.gov/pubmed/30568172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0319-2
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