An essential role for dNTP homeostasis following CDK-induced replication stress

Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is synthetic lethal with mutations disrupting dNTP homeostasis in fission yeast....

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Pai, Chen-Chun, Hsu, Kuo-Feng, Durley, Samuel C., Keszthelyi, Andrea, Kearsey, Stephen E., Rallis, Charalampos, Folkes, Lisa K., Deegan, Rachel, Wilkins, Sarah E., Pfister, Sophia X., De León, Nagore, Schofield, Christopher J., Bähler, Jürg, Carr, Antony M., Humphrey, Timothy C.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451416/
https://ncbi.nlm.nih.gov/pubmed/30674555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.226969
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