An essential role for dNTP homeostasis following CDK-induced replication stress

Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is synthetic lethal with mutations disrupting dNTP homeostasis in fission yeast....

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Pai, Chen-Chun, Hsu, Kuo-Feng, Durley, Samuel C., Keszthelyi, Andrea, Kearsey, Stephen E., Rallis, Charalampos, Folkes, Lisa K., Deegan, Rachel, Wilkins, Sarah E., Pfister, Sophia X., De León, Nagore, Schofield, Christopher J., Bähler, Jürg, Carr, Antony M., Humphrey, Timothy C.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451416/
https://ncbi.nlm.nih.gov/pubmed/30674555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.226969
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker