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Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies
Current Hi-C analysis approaches are unable to account for reads that align to multiple locations, and hence underestimate biological signal from repetitive regions of genomes. We developed and validated mHi-C, a multi-read mapping strategy to probabilistically allocate Hi-C multi-reads. mHi-C exhib...
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| Publicado no: | eLife |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450682/ https://ncbi.nlm.nih.gov/pubmed/30702424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38070 |
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