Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A

BACKGROUND: Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site. Recent structural analysis of CypA in complex with CA tubes...

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Publicado en:Retrovirology
Autores principales: Peng, Wang, Shi, Jiong, Márquez, Chantal L., Lau, Derrick, Walsh, James, Faysal, K. M. Rifat, Byeon, Chang H., Byeon, In-Ja L., Aiken, Christopher, Böcking, Till
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449974/
https://ncbi.nlm.nih.gov/pubmed/30947724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-019-0471-4
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