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Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects

BACKGROUND: Disassembly of the viral capsid following penetration into the cytoplasm, or uncoating, is a poorly understood stage of retrovirus infection. Based on previous studies of HIV-1 CA mutants exhibiting altered capsid stability, we concluded that formation of a capsid of optimal intrinsic st...

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Detalhes bibliográficos
Main Authors: Yang, Ruifeng, Shi, Jiong, Byeon, In-Ja L, Ahn, Jinwoo, Sheehan, Jonathan H, Meiler, Jens, Gronenborn, Angela M, Aiken, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351742/
https://ncbi.nlm.nih.gov/pubmed/22515365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-30
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