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Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A
BACKGROUND: Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site. Recent structural analysis of CypA in complex with CA tubes...
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| Publicado no: | Retrovirology |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6449974/ https://ncbi.nlm.nih.gov/pubmed/30947724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-019-0471-4 |
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