Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To understand the intrinsic capsid disassembly pathway and how it can be modulated, we have developed a single-particle fluorescence microscopy method t...

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Udgivet i:eLife
Main Authors: Márquez, Chantal L, Lau, Derrick, Walsh, James, Shah, Vaibhav, McGuinness, Conall, Wong, Andrew, Aggarwal, Anupriya, Parker, Michael W, Jacques, David A, Turville, Stuart, Böcking, Till
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039174/
https://ncbi.nlm.nih.gov/pubmed/29877795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34772
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