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Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

Oxazolidinones are synthetic antibiotics used for treatment of infections caused by Gram-positive bacteria. They target the bacterial protein synthesis machinery by binding to the peptidyl transferase centre (PTC) of the ribosome and interfering with the peptidyl transferase reaction. Cadazolid is t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Scaiola, Alain, Leibundgut, Marc, Boehringer, Daniel, Caspers, Patrick, Bur, Daniel, Locher, Hans H., Rueedi, Georg, Ritz, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449356/
https://ncbi.nlm.nih.gov/pubmed/30948752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42155-4
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