NAD(+) metabolism governs the proinflammatory senescence-associated secretome

Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). NAD(+) metabolism influences both tissue ageing and c...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Nacarelli, Timothy, Lau, Lena, Fukumoto, Takeshi, Zundell, Joseph, Fatkhutdinov, Nail, Wu, Shuai, Aird, Katherine M., Iwasaki, Osamu, Kossenkov, Andrew V., Schultz, David, Noma, Ken-ichi, Baur, Joseph A., Schug, Zachary, Tang, Hsin-Yao, Speicher, David W., David, Gregory, Zhang, Rugang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448588/
https://ncbi.nlm.nih.gov/pubmed/30778219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0287-4
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