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Selective Hydrogen Atom Abstraction via Induced Bond Polarization: The Direct α-Arylation of Alcohols via Photoredox, HAT and Nickel Catalysis

The combination of nickel metallaphotoredox catalysis, hydrogen atom transfer catalysis, and a Lewis acid activation mode, has led to the development of an arylation protocol for the selective functionalization of alcohol α-hydroxy C–H bonds. This approach employs zinc-mediated alcohol deprotonation...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Twilon, Jack, Christensen, Melodie, DiRocco, Daniel A., Ruck, Rebecca T., Davies, Ian W., MacMillan, David W. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448405/
https://ncbi.nlm.nih.gov/pubmed/29490112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201800749
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