Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib

Background: Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient therapeutic option in RA treatment, but less is known about the e...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Diller, Magnus, Hasseli, Rebecca, Hülser, Marie-Lisa, Aykara, Iris, Frommer, Klaus, Rehart, Stefan, Müller-Ladner, Ulf, Neumann, Elena
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448044/
https://ncbi.nlm.nih.gov/pubmed/30984167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00541
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