Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib

Background: Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient therapeutic option in RA treatment, but less is known about the e...

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Publicat a:Front Immunol
Autors principals: Diller, Magnus, Hasseli, Rebecca, Hülser, Marie-Lisa, Aykara, Iris, Frommer, Klaus, Rehart, Stefan, Müller-Ladner, Ulf, Neumann, Elena
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448044/
https://ncbi.nlm.nih.gov/pubmed/30984167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00541
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