Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib

Background: Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient therapeutic option in RA treatment, but less is known about the e...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Diller, Magnus, Hasseli, Rebecca, Hülser, Marie-Lisa, Aykara, Iris, Frommer, Klaus, Rehart, Stefan, Müller-Ladner, Ulf, Neumann, Elena
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448044/
https://ncbi.nlm.nih.gov/pubmed/30984167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00541
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