Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib

Background: Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient therapeutic option in RA treatment, but less is known about the e...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Diller, Magnus, Hasseli, Rebecca, Hülser, Marie-Lisa, Aykara, Iris, Frommer, Klaus, Rehart, Stefan, Müller-Ladner, Ulf, Neumann, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448044/
https://ncbi.nlm.nih.gov/pubmed/30984167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00541
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