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The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice
Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK is a multifunctional kinase that is a negative regulator of mechanistic target...
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| Publicado no: | Pharmacol Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447087/ https://ncbi.nlm.nih.gov/pubmed/30391353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2018.10.027 |
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